黒尾 代表取締役

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  1. Kuro-o M. Calcium phosphate microcrystallopathy as a paradigm of chronic kidney disease progression. Curr Opin Nephrol Hypertens. 2023; epub 4/19/2023.
  2. Mukai H, Miura Y, Kotani K, Kotoda A, Kurosu H, Yamada T, Kuro-o M, and Iwazu Y. The effects for inflammatory responses by CPP with different colloidal properties in hemodialysis patients. Sci Rep. 2022; 12: 21856.
  3. Yoshioka M, Kosaki K, Matsui M, Mori S, Nishitani N, Saito C, Yamagata K, Kuro-o M, and Maeda S. Association between the intake of plant and animal proteins and the serum fibroblast growth factor-23 level in patients with chronic kidney disease analyzed by the isocaloric substitution model. Endocr J. 2023; 70: 31-42.
  4. Akiyama K, Moriyama T, Hanafusa N, Miura Y, Seki M, Ushio Y, Kawasoe K, Miyabe Y, Karasawa K, Sugiura H, Uchida K, Okazaki M, Komatsu M, Kawaguchi H, Kuro-o M, Nitta K, and Hoshino J. Citric acid-based bicarbonate dialysate attenuates aortic arch calcification in maintenance hemodialysis patients: a retrospective observational study. J Nephrol. 2023; 36: 367-76.
  5. Nishitani N, Kosaki K, Matsui M, Sugaya T, Kuro-o M, Saito C, Yamagata K, and Maeda S. Association between trunk flexibility and renal flow pulsatility in middle-aged and older adults. Exp Gerontol. 2023; 172: 112060.
  6. Battulga B, Shiizaki K, Miura Y, Osanai Y, Yamazaki R, Shinohara Y, Kubota Y, Hara T, Kuro-o M, and Ohno N. Correlative light and electron microscopic observation of calcium phosphate particles in a mouse kidney formed under a high-phosphate diet. Sci Rep. 2023; 13: 852.
  7. González-Lafuente L, Navarro-García JA, Valero-Almazán Á, Rodríguez-Sánchez E, Vázquez-Sánchez S, Mercado-García E, Pineros P, Poveda J, Fernández-Velasco M, Kuro-o M, Ruilope LM, and Ruiz-Hurtado G. Partial Genetic Deletion of Klotho Aggravates Cardiac Calcium Mishandling in Acute Kidney Injury. Int J Mol Sci. 2023; 24: 1322.
  8. Jahan N, Ohsaki H, Kaneko K, Rahman A, Nishiyama T, Koizumi M, Yamanaka S, Kitada K, Sugiura Y, Matsui K, Yokoo T, Hamano T, Kuro-o M, Itou T, Suzuki M, Ueda K, and Nishiyama A. Possible contribution of phosphate to the pathogenesis of chronic kidney disease in dolphins. Sci Rep. 2023; 13: 5161.
  9. González-Lafuente L, Navarro-García JA, Rodríguez-Sánchez E, Aceves-Ripoll J, Poveda J, Vázquez-Sánchez S, Mercado-García E, Fernández-Velasco M, Kuro-o M, Liaño F, Ruilope LM, and Ruiz-Hurtado G. Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca2+ mishandling and preventive role of Klotho in mice to its potential mortality prediction in human. Transl Res. 2022; 243: 60-77.
  10. Hashimoto Y, Kato S, Kuro-o M, Miura Y, Itano Y, Ando M, Kuwatsuka Y, and Maruyama S. Impact of etelcalcetide on fibroblast growth factor-23 and calciprotein particles in patients with secondary hyperparathyroidism undergoing haemodialysis. Nephrology (Carlton). 2022; 27: 763-70.
  11. Kosaki K, Tarumi T, Mori S, Matsui M, Sugawara J, Sugaya T, Kuro-o M, Saito C, Yamagata K, Oka K, and Maeda S. Cerebral and renal hemodynamics: similarities, differences, and associations with chronic kidney disease and aortic hemodynamics. Hypertens Res. 2022; 45: 1363-72.
  12. Matsui M, Kosaki K, Myoenzono K, Yoshikawa T, Park J, Kuro-o M, and Maeda S. Effect of Aerobic Exercise Training on Circulating Fibroblast Growth Factor-21 Response to Glucose Challenge in Overweight and Obese Men: A Pilot Study. Exp Clin Endocrinol Diabetes. 2022; 130(11): 723-729.
  13. Mori S, Kosaki K, Matsui M, Takahashi K, Yoshioka M, Tarumi T, Sugawara J, Shibata A, Kuro-o M, Saito C, Yamagata K, Oka K, and Maeda S. Sedentary behavior is associated with reduced cardiovagal baroreflex sensitivity in healthy adults. Hypertens Res. 2022;45:1193-202.
  14. Nakamura K, Isoyama N, Nakayama Y, Hiroyoshi T, Fujikawa K, Miura Y, Kurosu H, Matsuyama H, and Kuro-o M. Association between amorphous calcium-phosphate ratios in circulating calciprotein particles and prognostic biomarkers in hemodialysis patients. Sci Rep. 2022; 12: 13030.
  15. Yajima A, Tsuchiya K, Kuro-o M, Urena P, Tominaga Y, Okada M, Ichimori T, Tomosugi T, Hiramitsu T, Murata T, Nakamura M, Sasaki M, Ito A, and Nitta K. Renal hyperparathyroidism. Vitam Horm. 2022; 120: 305-43.
  16. Yoshioka M, Kosaki K, Matsui M, Okabe N, Saito C, Yamagata K, Kuro-o M, and Maeda S. Association of circulating calciprotein particle levels with skeletal muscle mass and strength in middle-aged and older women. Hypertens Res. 2022; 45(5): 900-910.
  17. Yoshioka M, Kosaki K, Noma S, Matsui M, Kuro-o M, Shibata A, Saito C, Yamagata K, Oka K, and Maeda S. Daily behavioral and sleep patterns are associated with aging-induced male-specific disorders in individuals with reduced renal function. Exp Gerontol. 2022; 161: 111717.
  18. Matsui M, Kosaki K, Kuro-o M, Saito C, Yamagata K, Maeda S. Circulating fibroblast growth factor 21 links hemodynamics with kidney function in middle-aged and older adults: A mediation analysis. Hypertens Res. 2021; 45; 125-134.
  19. Yoshioka M, Kosaki K, Matsui M, Shibata A, Oka K, Kuro-o M, Saito C, Yamagata K, and Maeda S. Replacing sedentary time for physical activity on bone density in patients with chronic kidney disease. J Bone Miner Metab. 2021; 39: 1091-1100.
  20. Kosaki K, Takahashi K, Matsui M, Yoshioka M, Mori S, Nishitani N, Shibata A, Saito C, Kuro-o M, Yamagata K, Oka K, and Maeda S. Sedentary behavior and estimated nephron number in middle-aged and older adults with or without chronic kidney disease. Exp Gerontol. 2021; 154: 111531.
  21. Kosaki K, Tarumi T, Sugawara J, Tanahashi K, Kumagai H, Matsui M, Sugaya T, Osuka Y, Tanaka K, Kuro-o M, Saito C, Yamagata K, and Maeda S. Renal hemodynamics across the adult lifespan: Relevance of flow pulsatility to chronic kidney disease. Exp Gerontol. 2021; 152: 111459.
  22. Yoshioka M, Kosaki K, Matsui M, Takahashi K, Shibata A, Oka K, Kuro-o M, Saito C, Yamagata K, and Maeda S. Physical Activity, Sedentary Behavior, And Skeletal Muscle Strength In Patients With Chronic Kidney Disease: An Isotemporal Substitution Approach. Phys Ther. 2021; 7: 1-7.
  23. Shiizaki K, Tsubouchi A, Miura Y, Seo K, Kuchimaru T, Hayashi H, Iwazu Y, Miura M, Battulga B, Ohno N, Hara T, Kunishige R, Masutani M, Negishi K, Kario K, Kotani K, Yamada T, Nagata D, Komuro I, Itoh H, Kurosu H, Murata M, and Kuro-o M. Calcium phosphate microcrystals in the renal tubular fluid are an endogenous pathogen of tubular damage and nephron loss. J Clin Invest. 2021; 131(16): e145693.
  24. Navarro-García JA, Rueda A, Romero-García T, Aceves-Ripoll J, Rodríguez-Sánchez E, González-Lafuente L, Zaragoza C, Fernández-Velasco M, Kuro-o M, Ruilope LM, and Ruiz-Hurtado G. Enhanced Klotho availability protects against cardiac dysfunction induced by uraemic cardiomyopathy by regulating Ca2+ handling. Br J Pharmacol. 2020; 177(20):4701-19.
  25. Nakamura K, Nagata Y, Hiroyoshi T, Isoyama N, Fujikawa K, Miura Y, Matsuyama H, and Kuro-o M. The effect of lanthanum carbonate on calciprotein particles in hemodialysis patients. Clin Exp Nephrol. 2020; 24: 323-9.
  26. Matsui M, Kosaki K, Tanahashi K, Akazawa N, Osuka Y, Tanaka K, Kuro-o M, and Maeda S. Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults. Exp Gerontol. 2020; 141: 111081.
  27. Kuro-o M. Phosphate as a Pathogen of Arteriosclerosis and Aging. J Atheroscler Thromb. 2020; 28: 203-13.
  28. Kunishige R, Mizoguchi M, Tsubouchi A, Hanaoka K, Miura Y, Kurosu H, Urano Y, Kuro-o M, and Murata M. Calciprotein particle-induced cytotoxicity via lysosomal dysfunction and altered cholesterol distribution in renal epithelial HK-2 cells. Sci Rep. 2020; 10: 20125.
  29. Kletzmayr A, Bigler M, Montanari E, Kuro-o M, Hayashi H, Ivarsson ME, and Leroux J-C. Development of a Kidney Calcification Inhibitor Employing Image-Based Profiling: A Proof-of-Concept Study. ACS Pharmacol Translational Sci. 2020; 3(6): 1339-51.
  30. Jahnen-Dechent W, Büscher A, Köppert S, Heiss A, Kuro-o M, and Smith ER. Mud in the blood the role of protein-mineral complexes and extracellular vesicles in biomineralisation and calcification. J Struct Biol. 2020; 212: 107577.
  31. Hirano Y, Kurosu H, Shiizaki K, Iwazu Y, Tsuruoka S, and Kuro-o M. Interleukin-36a as a potential biomarker for renal tubular damage induced by dietary phosphate load. FEBS Open Bio. 2020; 10: 894-903.
  32. Gatate Y, Nakano S, Mizuno Y, Muramatsu T, Senbonmatsu T, Nishimura S, Kono R, Kaneko K, Miura Y, and Kuro-o M. Mid-term predictive value of calciprotein particles in maintenance hemodialysis patients based on a gel-filtration assay. Atherosclerosis. 2020; 303: 46-52.
  33. Voelkl J, Lang F, Eckardt KU, Amann K, Kuro-o M, Pasch A, Pieske B, and Alesutan I. Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia. Cell Mol Life Sci. 2019; 76: 2077-91.
  34. Nemoto Y, Kumagai T, Ishizawa K, Miura Y, Shiraishi T, Morimoto C, Sakai K, Omizo H, Yamazaki O, Tamura Y, Fujigaki Y, Kawachi H, Kuro-o M, Uchida S, and Shibata S. Phosphate binding by sucroferric oxyhydroxide ameliorates renal injury in the remnant kidney model. Sci Rep. 2019; 9: 1732.
  35. Navarro-Garcia JA, Delgado C, Fernandez-Velasco M, Val-Blasco A, Rodriguez-Sanchez E, Aceves-Ripoll J, Gomez-Hurtado N, Bada-Bosch T, Merida-Herrero E, Hernandez E, Praga M, Salguero R, Solis J, Arribas F, Delgado JF, Bueno H, Kuro-o M, Ruilope LM, and Ruiz-Hurtado G. Fibroblast growth factor-23 promotes rhythm alterations and contractile dysfunction in adult ventricular cardiomyocytes. Nephrol Dial Transplant. 2019; 34(11): 1864-75.
  36. Nakazato J, Hoshide S, Wake M, Miura Y, Kuro-o M, and Kario K. Association of calciprotein particles measured by a new method with coronary artery plaque in patients with coronary artery disease: A cross-sectional study. J Cardiol. 2019; 74: 428-35.
  37. Nakano T, Shiizaki K, Miura Y, Matsui M, Kosaki K, Mori S, Yamagata K, Maeda S, Kishi T, Usui N, Yoshida M, Onaka T, Mizukami H, Kaneda R, Karasawa K, Nitta K, Kurosu H, and Kuro-o M. Increased fibroblast growth factor-21 in chronic kidney disease is a trade-off between survival benefit and blood pressure dysregulation. Sci Rep. 2019; 9: 19247.
  38. Nakamura K, Nagata Y, Hiroyoshi T, Isoyama N, Fujikawa K, Miura Y, Matsuyama H, and Kuro-o M. The effect of lanthanum carbonate on calciprotein particles in hemodialysis patients. Clin Exp Nephrol. 2019; 24: 323-9.
  39. Kuro-o M. The Klotho proteins in health and disease. Nat Rev Nephrol. 2019;15:27-44.
  40. Jorge LB, Coelho FO, Sanches TR, Malheiros D, Ezaquiel de Souza L, Dos Santos F, de Sa Lima L, Scavone C, Irigoyen M, Kuro-o M, and Andrade L. Klotho deficiency aggravates sepsis-related multiple organ dysfunction. Am J Physiol Renal Physiol. 2019; 316: F438-f48.
  41. Akiyama K, Miura Y, Hayashi H, Sakata A, Matsumura Y, Kojima M, Tsuchiya K, Nitta K, Shiizaki K, Kurosu H, and Kuro-o M. Calciprotein particles regulate fibroblast growth factor-23 expression in osteoblasts. Kidney Int. 2019; 97: 702-12.
  42. Yamada H, Kuro-o M, Funazaki S, Ishikawa S-e, Kakei M, and Hara K. The Urinary Phosphate to Serum Fibroblast Growth Factor 23 Ratio, Deemed the Nephron Index, Is a Useful Clinical Index for Early Stage Chronic Kidney Disease in Patients with Type 2 Diabetes: An Observational Pilot Study. Int J Nephrol. 2018; 2018: 4.
  43. Wehling-Henricks M, Welc SS, Samengo G, Rinaldi C, Lindsey C, Wang Y, Lee J, Kuro-o M, and Tidball JG. Macrophages escape Klotho gene silencing in the mdx mouse model of Duchenne muscular dystrophy and promote muscle growth and increase satellite cell numbers through a Klotho-mediated pathway. Hum Mol Genet. 2018; 27: 14-29.
  44. Voelkl J, Tuffaha R, Luong TTD, Zickler D, Masyout J, Feger M, Verheyen N, Blaschke F, Kuro-o M, Tomaschitz A, Pilz S, Pasch A, Eckardt KU, Scherberich JE, Lang F, Pieske B, and Alesutan I. Zinc Inhibits Phosphate-Induced Vascular Calcification through TNFAIP3-Mediated Suppression of NF-kappaB. J Am Soc Nephrol. 2018; 29: 1636-48.
  45. Tsunezumi J, Sugiura H, Oinam L, Ali A, Thang BQ, Sada A, Yamashiro Y, Kuro-o M, and Yanagisawa H. Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice. Matrix Biol. 2018; 74: 5-20.
  46. Stenvinkel P, Painer J, Kuro-o M, Lanaspa M, Arnold W, Ruf T, Shiels PG, and Johnson RJ. Novel treatment strategies for chronic kidney disease: insights from the animal kingdom. Nat Rev Nephrol. 2018; 14: 265-84.
  47. Saulnier-Blache JS, Wilson R, Klavins K, Graham D, Alesutan I, Kastenmuller G, Wang-Sattler R, Adamski J, Roden M, Rathmann W, Seissler J, Meisinger C, Koenig W, Thiery J, Suhre K, Peters A, Kuro-o M, Lang F, Dallmann G, Delles C, Voelkl J, Waldenberger M, Bascands JL, Klein J, and Schanstra JP. Ldlr-/- and ApoE-/-mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease. Atherosclerosis. 2018; 276: 140-7.
  48. Navarro-Garcia JA, Fernandez-Velasco M, Delgado C, Delgado JF, Kuro-o M, Ruilope LM, and Ruiz-Hurtado G. PTH, vitamin D, and the FGF-23-klotho axis and heart: Going beyond the confines of nephrology. Eur J Clin Invest. 2018; 48: e12902.
  49. Miura Y, Iwazu Y, Shiizaki K, Akimoto T, Kotani K, Kurabayashi M, Kurosu H, and Kuro-o M. Identification and quantification of plasma calciprotein particles with distinct physical properties in patients with chronic kidney disease. Sci Rep. 2018; 8: 1256.
  50. Kuro-o M. Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System. Int J Nephrol. 2018; 2018: 9679841.
  51. Kuro-o M. Klotho and endocrine fibroblast growth factors: marker of chronic kidney disease progression and cardiovascular complications? Nephrol Dial Transplant. 2018;34:15-21.
  52. Kuro-o M. Ageing-related receptors resolved. Nature. 2018; 553: 409-10.
  53. Kozawa S, Ueda R, Urayama K, Sagawa F, Endo S, Shiizaki K, Kurosu H, Maria de Almeida G, Hasan SM, Nakazato K, Ozaki S, Yamashita Y, Kuro-o M, and Sato TN. The Body-wide Transcriptome Landscape of Disease Models. iScience. 2018; 2: 238-68.
  54. Kimura T, Shiizaki K, Akimoto T, Shinzato T, Shimizu T, Kurosawa A, Kubo T, Nanmoku K, Kuro-o M, and Yagisawa T. The impact of preserved Klotho gene expression on antioxidative stress activity in healthy kidney. Am J Physiol Renal Physiol. 2018; 315: F345-f52.
  55. Coelho FO, Jorge LB, de Braganca Viciana AC, Sanches TR, Dos Santos F, Helou CMB, Irigoyen MC, Kuro-o M, and Andrade L. Chronic nicotine exposure reduces klotho expression and triggers different renal and hemodynamic responses in klotho-haploinsufficient mice. Am J Physiol Renal Physiol. 2018; 314: F992-F8.

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小﨑 取締役

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リンク：researchmap, J-GLOBAL

  1. Yoshioka, M., Kosaki, K., Matsui, M., Mori, S., Nishitani, N., Saito, C., Yamagata, K., Kuro-o, M., Maeda, S. Association between the intake of animal and plant proteins and the serum fibroblast growth factor-23 level in patients with chronic kidney disease analyzed by the isocaloric substitution model. Endocrine Journal, 2023, 70(1), 31-42.
  2. Nishitani, N., Kosaki, K., Matsui, M., Sugaya, T., Kuro-o, M., Saito, C., Yamagata, K., Maeda, S. Association between trunk flexibility and renal flow pulsatility in middle-aged and older adults. Experimental Gerontology, 2022, 172, 112060.
  3. Mori, S., Kosaki, K., Tagata, R., Kon, K., Yasuda, R., Nishitani, N., Ishizu, T., Maeda, S. Acute influences of tennis services on cardiac output and brachial hemodynamics in young male tennis players. Journal of Science and Medicine in Sport, 2022, 25(12), 973-978.
  4. Sato, T. Kosaki, K., Choi, Y., Tochigi, Y., Shindo-Hamasaki, A., Momma, R., Maeda, S. Association between sport types and visuospatial working memory in athletes. The Journal of Physical Fitness and Sports Medicine, 2022, 11(4), 247-253.
  5. Matsui, M., Kosaki, K., Myoenzono, K., Yoshikawa, T., Park, J., Kuro-o, M., Maeda, S. Effect of aerobic exercise training on circulating fibroblast growth factor-21 response to glucose challenge in overweight and obese men: a pilot study. Experimental and Clinical Endocrinology & Diabetes, 2022, 130(11), 723-729.
  6. Kosaki, K., Kumamoto, S., Tokinoya, K., Yoshida, Y., Sugaya, T., Murase, T., Akari, S., Nakamura, T., Nabekura, Y., Takekoshi, K., Maeda, S. Xanthine Oxidoreductase Activity in Marathon Runners: Pothetial Implications for Marathon-Induced Acute Kidney Injury. Journal of Applied Physiology, 2022, 133(1), 1-10.
  7. Kosaki, K., Tarumi, T., Mori, S., Matsui, M., Sugawara, J., Sugaya, T., Kuro-o, M., Saito, C., Yamagata, K., Oka, K., Maeda, S. Cerebral and Renal Hemodynamics: Similarities, Differences, and Associations with Chronic Kidney Disease and Aortic Hemodynamics. Hypertension Research, 2022, 45(8), 1363-1372.
  8. Mori, S., Tarumi, T., Kosaki, K., Matsui, M., Yoshioka, M., Sugawara, J., Kuro-o, M., Saito, C., Yamagata, K., Maeda, S. Effect of Sit-Stand Maneuver on Baroreflex Sensitivity and Cardiovascular Disease Risk Assessments. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2022, 322(5), R400-R410.
  9. Yoshioka, M., Kosaki, K., Noma, S., Matsui, M., Kuro-o, M., Shibata, A., Saito, C., Yamagata, K., Oka, K., Maeda, S. Daily behavioral and sleep patterns are associated with aging-induced male-specific disorders in individuals with reduced renal function. Experimental Gerontology, 2022, 161, 111717.
  10. Kosaki, K., Yokota, A., Tanahashi, K., Nakamura, T., Murase, T., Akari, S., Myoenzono, K., Yoshikawa, T., Maeda, S. Associations of plasma xanthine oxidoreductase activity with markers of cardiometabolic risk in overweight/obese men. Journal of Clinical Biochemistry and Nutrition, 2022, 71(2), 122-128.
  11. Mori, S., Kosaki, K., Matsui, M., Takahashi, K., Yoshioka, M., Tarumi, T., Sugawara, J., Shibata, A., Kuro-o, M., Saito, C., Yamagata, K., Oka, K., Maeda, S. Sedentary behavior is associated with reduced cardiovagal baroreflex sensitivity in normal healthy adults. Hypertension Research, 2022, 45(7), 1193-1202.
  12. Yoshioka, M., Kosaki, K., Matsui, M., Okabe, N., Saito, C., Yamagata, K., Kuro-o, M., Maeda, S. Association of circulating calciprotein particle levels with skeletal muscle mass and strength in middle-aged and older women. Hypertension Research, 2022, 45(5), 900-910.
  13. Park, J., Kosaki, K., Myoenzono, K., Choi, Y., Tsujimoto, T., Shimojo, N., Maeda, S. Effects of aerobic exercise training on circulating angiopoietin-like protein 2 in overweight and obese men: a pilot study. Journal of Men’s Health, 2022, 18(3), 53.
  14. Matsui, M., Kosaki, K., Kuro-o, M., Saito, C., Yamagata, K., Maeda, S. Circulating fibroblast growth factor 21 links hemodynamics with kidney function in middle-aged and older adults: A mediation analysis. Hypertension Research, 2021, 45(1), 125-134.
  15. Kosaki, K., Takahashi, K., Matsui, M., Yoshioka, M., Mori, S., Nishitani, N., Shibata, A., Saito, C., Kuro-o, M., Yamagata, K., Oka, K., Maeda, S. Sedentary behavior and estimated nephron number in middle-aged and older adults with or without chronic kidney disease. Experimental Gerontology, 2021, 154, 111531.
  16. Akazawa, N., Tanahashi, K., Kosaki, K., Oikawa, S., Kumagai, H., Maeda, S. Effects of aerobic exercise training on mental health and arterial stiffness in middle-aged and older adults. The Journal of Sports Medicine and Physical Fitness, 2021, 61(10), 1387-1392.
  17. Kosaki, K., Tarumi, T., Sugawara, J., Tanahashi, K., Kumagai,H., Matsui, M., Sugaya, T., Osuka, Y., Tanaka, K., Kuro-o, M., Saito, C., Yamagata, K., Maeda, S. Renal hemodynamics across the adult lifespan: Relevance of flow pulsatility to chronic kidney disease. Experimental Gerontology, 2021, 152, 111459.
  18. Shiomi, K., Saito, C., Nagai, K., Kosaki, K., Kawamura, T., Kaneko, S., Kai, H., Morito, N., Usui, J., Yanagi, H., Yamagata K. Ratio of serum creatinine to cystatin C is related to leg strength in predialysis CKD patients. Clinical and Experimental Nephrology, 2021, 25(10), 1079-1086.
  19. Yoshioka, M., Kosaki, K., Matsui, M., Shibata, A., Oka, K., Kuro-o, M., Saito, C., Yamagata, K., Maeda, S. Replacing sedentary time for physical activity on bone density in patients with chronic kidney disease. Journal of Bone and Mineral Metabolism, 2021, 39(6), 1091-1100.
  20. Yoshioka, M., Kosaki, K., Matsui, M., Takahashi, K., Shibata, A., Oka, K., Kuro-o, M., Saito, C., Yamagata, K., Maeda, S. Physical activity, sedentary behavior, and skeletal muscle strength in patients with chronic kidney disease: An isotemporal substitution approach. Physical Therapy, 2021, 101(7), pzab101.
  21. Akazawa, N., Tanahashi, K., Kosaki, K., Kumagai, H., Oikawa, S., Hamasaki, A., Maeda, S. The Impact of aerobic fitness on arterial stiffness and adrenal cortex hormones in middle-aged and older adults. Endocrine Journal, 2020, 67(12), 1199-1205.
  22. Akazawa, N., Tanahashi, K., Kosaki, K., Hamasaki, A., Maeda, S. Association between mental health and arterial stiffness in middle-aged and older adults. Artery Research, 2020, 26(4), 223-227.
  23. Yoshida, Y., Kosaki, K., Sugasawa, T., Matsui, M., Yoshioka, M., Aoki, K., Kuji, T., Mizuno, R., Kuro-o, M., Yamagata, K., Maeda, S., Takekoshi, K. High salt diet impacts the risk of sarcopenia associated with reduction of skeletal muscle performance in the Japanese population. Nutrients, 2020, 12(11), 3474.
  24. Matsui, M., Kosaki, K., Tanahashi, K., Akazawa, N., Osuka, Y., Tanaka, K., Kuro-o, M., Maeda, S. Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults. Experimental Gerontology, 2020, 141, 111081.
  25. Kosaki, K., Tanahashi, K., Matsui, M., Akazawa, N., Osuka, Y., Tanaka, K., Dunstan, DW., Owen, N., Shibata, A., Oka, K., Maeda, S. Sedentary behaviour, physical activity, and renal function in older adults: Isotemporal substitution modelling. BMC Nephrology, 2020, 21, 211.
  26. Tanabe, J., Ogura, Y., Kosaki, K., Nagai, Y., Sugaya, T., Ohata, K., Watanabe, S., Ichikawa, D., Inoue, K., Hoshino, S., Kimura, K., Maeda, S., Shibagaki, Y., Kamijo-Ikemori, A. Relationship between urinary liver-type fatty acid-binding protein (L-FABP) and sarcopenia in spontaneously diabetic Torii fatty rats. Journal of Diabetes Research, 2020, 7614035.
  27. Kumagai, H., Yoshikawa, T., Kosaki, K., Myoenzono, K., Maeda, S. Deterioration of sexual function is associated with central hemodynamics in Japanese adult men. Hypertension Research, 43(1), 36-44.
  28. Nakano, T., Shiizaki, K., Miura, Y., Matsui, M., Kosaki, K., Mori, S., Yamagata, K., Maeda, S., Kishi, T., Usui, N., Yoshida, M., Onaka, T., Mizukami, H., Kaneda, R., Karasawa, K., Nitta, K., Kurosu, H., Kuro-o, M. Increased fibroblast growth factor-21 in chronic kidney disease is a trade-off between survival benefit and blood pressure dysregulation. Scientific Reports, 2019, 9(1), 19247.
  29. Kosaki K., Kamijo-Ikemori, A., Sugaya, T., Kumamoto, S., Tanahashi, K., Kumagai, H., Kimura, K., Shibagaki, Y., Maeda, S. Incremental short maximal exercise increases urinary liver-type fatty acid-binding protein in adults without CKD. Scandinavian Journal of Medicine and Science in Sports, 2020, 30(4), 709-715.
  30. Kosaki, K., Osuka, Y., Tanaka, K., Maeda, S. Effect of resistance training combined with aerobic exercise on aortic arterial stiffness in older adults: a secondary analysis of randomized controlled trial. The Journal of Physical Fitness and Sports Medicine, 2019, 8(5), 203-208.
  31. Matsui, M., Kosaki, K., Akazawa, N., Tanahashi, K., Kuro-o, M., Maeda, S. Association between circulating fibroblast growth factor 21, aerobic fitness, and aortic blood pressure in middle-aged and older women. The Journal of Sports Medicine and Physical Fitness. 2019, 8(5), 195-201.
  32. Sone, R., Eda, N., Kosaki, K., Endo, M., Watanabe, K. Influence of acute high-intensity exercise on salivary nitric oxide levels. Journal of Oral Science, 2019, 61(2), 307-312.
  33. Kosaki, K., Sugaya, T., Ohata, K., Tanabe, J., Hoshino, S., Inoue, K., Kimura, K., Maeda, S., Shibagaki, Y., Kamijo-Ikemori, A. Renoprotective effects of voluntary running exercise training on aldosterone-induced renal injury in human L-FABP chromosomal transgenic mice. Hypertension Research, 2019, 42(10), 1518-1527.
  34. Kumagai, H., Yoshikawa, T., Myoenzono, K., Kosaki, K., Akazawa, N., Tanahashi, K., Tagawa, K., Zempo-Miyaki, A., Maeda, S. Role of high physical fitness against deterioration of male sexual function in Japanese adult men. American Journal of Men's Health, 2019, 13(3), 1557988319849171.
  35. Sone, R., Matsuba, K., Tahara, R., Eda, N., Kosaki, K., Jesmin, S., Miyakawa, S., Watanabe K. Assessment of salivary nitric oxide levels in elite university athletes in Japan: findings from a cross sectional study design. Journal of Clinical Medicine Research, 2019, 11(2), 114-120.
  36. Akazawa, N., Hamasaki, A., Tanahashi, K., Kosaki, K., Yoshikawa, T., Myoenzono, K., Maeda S. Lactotripeptide ingestion increases middle cerebral blood flow velocity in middle-aged and older adults. Nutrition Research, 2018, 53,61-66.
  37. Kumagai, H., Yoshikawa, T., Myoenzono, K., Kosaki, K., Akazawa, N., Zempo-Miyaki, A., Tsujimoto, T., Kidokoro, T., Tanaka, K., Maeda, S. Sexual function is an indicator of central arterial stiffness and arterial stiffness gradient in Japanese adult men. Journal of the American Heart Association, 2018, 7(10), e007964.
  38. Kosaki, K., Kamijo-Ikemori, A., Sugaya, T., Tanahashi, K., Akazawa, N., Hibi, C., Nakamura, T., Murase, T., Kimura, K., Shibagaki, Y., Maeda, S. Habitual exercise decreases plasma xanthine oxidoreductase activity in middle-Aged and older women. Journal of Clinical Biochemistry and Nutrition, 2018, 62(2), 1-7.
  39. Akazawa, N., Tanahashi, K., Kosaki, K., Ra, S.G., Matsubara, T., Choi, Y., Zempo-Miyaki, A., Maeda, S. Aerobic exercise training enhances cerebrovascular pulsatility response to acute aerobic exercise in older adults. Physiological Reports, 6(8), e13681.
  40. Kosaki, K., Sugawara, J. Zempo-Miyaki, A. Maeda, S. Impact of leg heating on central hemodynamics in postmenopausal women. Artery Research, 2018, 21(C), 53-57.
  41. Kosaki, K., Kamijo-Ikemori, A., Sugaya, T., Tanahashi, K., Sawano, Y., Akazawa, N., Ra, S-G., Kimura, K., Shibagaki, Y., Maeda, S. Effect of habitual exercise on urinary liver-type fatty acid-binding protein levels in middle-aged and older adults. Scandinavian Journal of Medicine and Science in Sports, 2018, 28 (1), 152-160.

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  1. Mori S, Kosaki K, Tagata R, Kon K, Yasuda R, Nishitani N, Ishizu T, Maeda S. Acute influences of tennis services on cardiac output and brachial hemodynamics in young male tennis players. Journal of Science and Medicine in Sport. 2022. 25(12): 973-978. PMID: 36357270
  2. Mori S, Tarumi T, Kosaki K, Matsui M, Yoshioka M, Sugawara J, Kuro-o M, Saito C, Yamagata K, Maeda S. Effects of the number of sit-stand maneuver repetitions on baroreflex sensitivity and cardiovascular risk assessments. American Journal Physiology, Regulatory, Integrative and Comparative Physiology. 2022. 322(5):R400-R410. PMID: 35293262
  3. Mori S, Kosaki K, Matsui M, Takahashi K, Yoshioka M, Tarumi T, Sugawara J, Shibata A, Kuro-o M, Saito C, Yamagata K, Oka K, Maeda S. Sedentary behavior is associated with reduced cardiovagal baroreflex sensitivity in healthy adults. Hypertension Research. 2022, 45(7):1193-1202. PMID: 35379916
  4. Nishitani N, Kosaki K, Mori S, Matsui M, Sugaya T, Kuro-o M, Saito C, Yamagata K, Maeda S. Association of Lower Extremity Muscle Strength and Function with Renal Resistive Index in Individuals with and without Chronic Kidney Disease. Geriatrics. 2023. 8. 6. 118-118. PMID: 38132489
  5. Yoshioka M, Kaneko T, Yoneko K, Matsui M, Mori S, Nishitani N, Wenxing Q, Ouchi K, Yasuda R, Namatame H, et al. Effects of lactotripeptide ingestion and physical activity intervention on the fatigue status of middle-aged and older adults: a randomized controlled trial. Scientific Reports. 2023. 13. 15736. PMID: 37735182
  6. Yoshioka M, Kosaki K, Matsui M, Mori S, Nishitani N, Saito C, Yamagata K, Kuro-o M, Maeda S. Association between the intake of plant and animal proteins and the serum fibroblast growth factor-23 level in patients with chronic kidney disease analyzed by the isocaloric substitution model. Endocrine Journal. 2023, 70(1):31-42. Link
  7. Kosaki K, Tarumi T, Mori S, Matsui M, Sugawara J, Sugaya T, Kuro-o M, Saito C, Yamagata K, Oka K, Maeda S. Cerebral and renal hemodynamics: similarities, differences, and associations with chronic kidney disease and aortic hemodynamics. Hypertension Research. 2022, 45(8), 1363-1372. PMID: 35665784
  8. Kosaki K, Takahashi K, Matsui M, Yoshioka M, Mori S, Nishitani N, Shibata A, Saito C, Kuro-o M, Yamagata K, Oka K, Maeda S. Sedentary behavior and estimated nephron number in middle-aged and older adults with or without chronic kidney disease. Exp Gerontol 154:111531, 2021. PMID: 34450233
  9. Nakano T, Shinzaki K, Miura Y, Matsui M, Kosaki K, Mori S, Yamagata K, Maeda S, Kishi T, Usui N, Yoshida M, Onaka T, Mizukami H, Kaneda R, Karasawa K, Nitta K, Kurosu H, Kuro-o M. Increased fibroblast growth factor-21 in chronic kidney disease is a trade-off between survival benefit and blood pressure dysregulation. Scientific Reports, 9 (1), 19247, 2019. PMID: 31848393